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Figure Caption
Fig. 2 mdm2 MO-injected mutant tp53 embryos are resistant to mdm2 loss-associated phenotypes due to mutant p53 LOF. Single cell embryos were injected with 0.7 mM of a splice-blocking mdm2 morpholino. Images were captured at 72 hpf. Representative images shown for each group as described by ratio in bottom right corner of each image, from four independent experiments. Scale bars, 300 μm.
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Reprinted from Biochimica et biophysica acta. Molecular basis of disease, 1871, Kobar, K., Tuzi, L., Fiene, J.A., Burnley, E., Galpin, K.J.C., Midgen, C., Laverty, B., Subasri, V., Wen, T.T., Hirst, M., Moksa, M., Carles, A., Cao, Q., Shlien, A., Malkin, D., Prykhozhij, S.V., Berman, J.N., tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes, 167612167612, Copyright (2024) with permission from Elsevier. Full text @ BBA Molecular Basis of Disease