ZFIN Image: Ahlmann-Eltze et al., 2025, Fig. 6

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Figure Caption

Fig. 6 Analysis of a spatial single-cell experiment.

a–d, UMAPs of cells from the hippocampi of four mice and spatial maps for two of them, colored by amyloid-β plaque density (calculated from smoothed and normalized fluorescent images²⁶) (a), whether the cell is a neuron (b), LEMUR-predicted differential expression (log₂ fold change) for Jun (c) and whether the cell is inside the differential expression neighborhood for Jun (d). e, Scatterplot of Jun expression as a function of plaque density for cells inside the neighborhood, neurons not in the neighborhood and all other cells. The line is a local regression (LOESS) fit through the pseudobulked values. Coord., coordinate.

Acknowledgments

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