Figure 4

Figure 4

Correlation of IL-6 and PD-1 expression levels with T-cell exhaustion markers in lung cancer patients. (A) Distribution of immune cells in the NSCLC single-cell sequencing data (EMTAB6149). (B) Distribution of CD352, TIM3, CD39, and PD1 expression in the NSCLC single-cell sequencing data (EMTAB6149). (C) Correlation of the PD1⁺CD8⁺T-cell ratio with the CD352⁺CD8⁺ T-cell ratio in lung cancer patients. (D) Correlation between the PD1⁺ CD8⁺ T-cell ratio and the TIM3⁺CD8⁺ T-cell ratio in lung cancer patients. (E) Correlation between the PD1⁺CD8⁺T-cell ratio and CD39⁺CD8⁺ T-cell ratio in lung cancer patients. (F) Correlation between the PD1⁺CD8⁺ T-cell ratio and IL-6 expression in lung cancer patients. (G) Heatmap analysis of the correlation between IL-6 and PD1, TIM3, NRP1, CD352, and CD39 in patients with lung cancer. ns, not statistically significant. *P < 0.05, **P < 0.01, ***P < 0.001.