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Fig. 4 Prioritization of pharmaceuticals in effluents in England and Japan based on predicted antagonistic EQs against human and zebrafish receptors. Bars indicate predicted antagonistic EQs of each GPCR-acting pharmaceutical in effluents. For each GPCR, overall predicted antagonistic EQs are the sum of individual activities of the most consumed pharmaceuticals against each receptor following the concentration addition model. Parentheses show the unit and corresponding reference antagonistic pharmaceuticals for each receptor.
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