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Figure 8.
Experimentally solved structures of EX527 analogue bound to (a) SIRT1, as revealed by the PDB entry 4I5I. (b) EX527 bound to SIRT3 in the PDB entry 4BVH, (c) Taxol molecule bound to a tubulin unit, as presented by the PDB entry 6WVR. The distinct chemical nature of the ligands, variations in size, and differences in the characteristics of their respective binding pockets render it improbable for them to engage in competition for the same binding site.
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Full text @ J Enzyme Inhib Med Chem