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Fig. 3 Comparative transcriptomic analysis for identifying key genes involved in IB development. A Identification of one-to-one orthologous gene pairs across different species. A total of 19,997 one-to-one orthologous gene pairs were identified in the IB-containing group, and 15,818 one-to-one orthologous gene pairs were identified in the IB-containing vs. IB-lacking fish group. A total of 3302 genes were specific to the IB-containing fish group. B Identification of 623 IB-related differentially expressed genes in the IB-containing fish group. Gene set enrichment analysis was performed on this gene set. C Grouping of differentially expressed genes identified from the IB-containing fish group (left plot) and the IB-containing vs. IB-lacking fish group (right plot). D Expression patterns of genes from different groups in C during IB development. E Lollipop plot displaying IB-containing-fish specific differentially expressed genes and orthologous differentially expressed genes. F Functional network plot of selected differentially expressed genes