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Fig. 3 Zebrafish cardiac output, heart rate, and behavioural acquisition. (A) Relief of heart failure in zebrafish observed by ventricular filling, ventricular ejection, and isovolumic diastole conditions. The location of heart is shown as a dotted line. (B) Changes in the dynamic gray values of the zebrafish heart. (C) Under 80 ?M VPH exposure, heart rate was significantly increased in the 40 ?M RES group compared to the VPH modeling group. (D) Under 80 ?M VPH exposure, heart output was significantly restored in the 40 ?M RES group compared to the VPH modeling group. (E) Behavioural tracks (left) and heatmap (right) of trajectories. (F) Zebrafish behavioural distance analysis. (Compared with the control group: *: P < 0.05, **: P < 0.05, ***: P < 0.001, ****: P < 0.0001, NS: not statistically different).