ZFIN Image: Chen et al., 2025, Figure 7

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Figure Caption

Figure 7

Type 2 diabetes mellitus (T2DM) inhibits NAMPT expression by upregulating miR-139a-5p. (a–c) T2DM significantly downregulates NAMPT mRNA and protein expression in the skeletal muscle of zebrafish. (d) T2DM significantly decreased NAD⁺ content in the skeletal muscle of zebrafish. (e) Using bioinformatics, we predicted that NAMPT is the target gene of miR-139a-5p; the red part is the seed region of NAMPT, and the blue part is the binding site between miR-139a-5p and the NAMPT seed region. (f) T2DM significantly upregulates miR-139a-5p in skeletal muscle. (g) The dual-luciferase reporter assay showed a regulatory relationship between miR-139a-5p and NAMPT. * p < 0.05, ** p < 0.01, *** p < 0.001. (n = 3 samples per group).

Acknowledgments

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