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Fig. 1 Antimicrobial screening of Actinomycetota isolated from C. crispus (CC) and C. tomentosum (CT). (A) Strains with bioactivity in the antimicrobial assay. Only strains active towards at least one reference microorganism are presented. Data displayed as average measurement (mm) of the inhibition halos (IH) diameter from two independent experiments. Strains highlighted in bold presented inhibitory effect towards the growth of at least one human and fish health-relevant reference microorganism. (B) Distribution of active and non-active strains retrieved from CC and CT. (C) Distribution of active strains according to their fermentation medium. (D) Genus-level taxonomic distribution of active strains. Taxonomic groups highlighted in bold were found in both macroalgae. The source of isolation, holdfast (●) or blade (▲), is indicated in all graphs.