Figure 6

Figure 6

Examples of fluorescent dextran intensity profiles over time measured on different xenografted zebrafish samples at different distances from the injection point. Solid lines are the best fit with D=1.9±0.22μm2s  (a) and D=0.82±0.02μm2s  (b). (c) Trend of the half value time τ12 as a function of the distance, R0, of the observation volume from the injection volume for control embryos (open squares) and for three different xenotransplanted embryos (filled squares, half-filled squares and circles). Solid lines correspond to the simulations for D = 10μm2s and t0=1800 s, 1200s, 600 s, 300 s, from top to bottom. The dashed lines correspond to the simulations for D = 4μm2s and t0=1200 s, 600 s, 450 s, from top to bottom. The dotted lines are the best fit linear trends to the data.