Figure 2

Figure 2

Hyperaminoacidemia, but not GLP-1, contributes to the increased pancreas mass in the GCGR-Ab-treated mice

(A) Schematic of experimental design in Glp1r−/− and control mice.

(B) Pancreas mass in Glp1r−/− mice treated with IgG or GCGR-Ab (n = 9–11/treatment). ∗∗∗p < 0.001. Student’s t test.

(C) Experimental outline depicting the treatment of IGS-induced pancreas expansion by a low protein diet.

(D) Relative pancreas weight in Gcgr^hep−/− and control mice on 20% or 6% protein diet.

(E) Total blood aa in Gcgr^hep−/− and control mice on 20% or 6% protein diet.

(F) Experimental outline to prevent IGS-induced pancreas expansion.

(G) Relative pancreas weight in Gcgr^hep−/− and control mice on 20% or 6% protein diet.

(H) Total blood aa in Gcgr^hep−/− and control mice on 20% or 6% protein diet. Data are represented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. One-way ANOVA followed by Turkey’s multiple comparisons tests.