ZFIN Image: Fietta et al., 2024, Fig 3

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Figure Caption

Fig 3 Internalization of NB-derived EVs by endothelial cells.

A-B. Injection site, imaging site, and timeline for the transgenic line Tg(fli1:EGFP) injected with labeled NB-derived EVs (red) at 48 hpf. The CHT was imaged after 6 hours to evaluate internalization by endothelial cells (green). C. Representative 6 hpi CHT images of internalized EVs derived from each cell line and oxygenation condition as indicated. Scale bars 50 μm. D. Higher magnification images in selected areas. White arrows indicate overlapping areas (yellow) of labeled EVs (red) internalized by endothelial cells (green). Scale bars 10 μm. E. Evaluation of internalization of labeled EVs by endothelial cells via ImageJ software. n = 88 from at least 3 independent experiments. *** p < 0.001.

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