|
Fig. 11 In vivo immunomodulatory effects in transgenic fluorescent zebrafish Tg (Lyz: EGFP). Scale bar is 100 ?m. A: treated with vinorelbine (150 ?g/mL), lipid (40 ?g/mL), paeonol (2.5, 5, 10, 20, 30, and 40 ?g/mL), and PAE-ethosomes (2.5, 5, 10, 20, 30, and 40 ?g/mL). B: number of macrophages in zebrafish after treatment with vinorelbine (150 ?g/mL), paeonol, and PAE-ethosomes (2.5, 5, 10, 20, 30, and 40 ?g/mL). The data were analyzed by one-way ANOVA followed by Dunnett?s test using Graph Pad Prism 7.0 (GraphPad Software; CA, USA). The results were expressed as mean ± SD, **P < 0.01, ***P < 0.001 VS Ctrl.