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Fig. 11 In vivo immunomodulatory effects in transgenic fluorescent zebrafish Tg (Lyz: EGFP). Scale bar is 100 μm. A: treated with vinorelbine (150 μg/mL), lipid (40 μg/mL), paeonol (2.5, 5, 10, 20, 30, and 40 μg/mL), and PAE-ethosomes (2.5, 5, 10, 20, 30, and 40 μg/mL). B: number of macrophages in zebrafish after treatment with vinorelbine (150 μg/mL), paeonol, and PAE-ethosomes (2.5, 5, 10, 20, 30, and 40 μg/mL). The data were analyzed by one-way ANOVA followed by Dunnett’s test using Graph Pad Prism 7.0 (GraphPad Software; CA, USA). The results were expressed as mean ± SD, **P < 0.01, ***P < 0.001 VS Ctrl.