Fig. 1

Fig. 1

Acral melanoma (AM) tumors highly amplify and/or upregulate RTK adapter proteins, VEGFR, FGFR, and FGF ligands (A) From 88 tumors in the Wang 2023 cohort, the percentage of tumors bearing RTK-associated allele loss, (B) amplification, or (C) high copy-number amplification above 4x background tumor ploidy are shown. D In comparison to CM, AM highly express RTK and intracellular RTK adapters (CRKL and GAB2) per Weiss 2022 [6]. Certain ligands such as FGF3 and FGF19 were expressed at low levels in some AM tumors compared to lack of expression in CM. P-adjusted significance values are indicated as follows: ~ p = 0.05–0.07, * p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, † low expression gives error in p-value calculations. E Large insertion and deletion (InDel) events and (F) translocation events involving RTK-associated genes occur in a minority of AM per Liang 2017 [84] and Newell 2020 [4]. G A summary of published CNV and expression results for select genes are tabulated