IMAGE

Fig 8

ID
ZDB-IMAGE-241122-3
Source
Figures for Tanwar et al., 2024
Image
Figure Caption

Fig 8 MCU complex mediated mitochondrial Ca2+ dynamics regulates pigmentation via NFAT2-Keratin5 signaling module.

Graphical summary of the work illustrating that silencing of MCU decreases melanogenesis while MCUb knockdown enhances melanogenesis. Transcription factor NFAT2 gets activated upon MCU silencing and that in turn induces keratin5 expression. Keratin5 drives melanogenesis by augmenting melanosome biogenesis and maturation. MCU, mitochondrial calcium uniporter.

Acknowledgments
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