ZFIN Image: Yin et al., 2024, Fig. 4

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Fig. 4

CoM cells secrete lactate and maintain their glycolytic properties in xenograft models. a Schematic representation of the glycolysis pathway with key enzymes in the process, showing the effect of 2DG inhibiting the activity of Hexokinase 1 (HK1). b Quantification of cell viability during treatment of increasing 2DG concentrations for 24 h. c The cellular ATP level of 67NR and 4T1, CRMM1, and CRMM2 after 2DG treatment. d 2DG inhibited the lactate production in 67NR and 4T1, CRMM1, and CRMM2 cells. e Expression of the glycolysis-related enzymes HK1, PFK1, PDK, and LDHA in zebrafish 4T1, 67NR, CRMM1 and CRMM2 xenografts

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