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Fig. 4 The frequency of neighbor exchange in the developing notochord was attenuated between PAPC?C-expressing cells in a homophilic contact. (A, B) Pairs of cells in direct contact (white and red dots) were chosen and tracked for as long as they were within the field of view. Neighbor exchange was recorded when a third cell (blue dot) appeared between the original cell pair. Scale bars, 25 ?m. (C) The frequency of neighbor exchange was significantly reduced in pairs of PAPC?C-expressing cells. Fifty pairs (n = 50) from three independent experiments (N = 3) were analyzed for each pairing. P values were determined by Tukey?s HSD test after one-way ANOVA.