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Fig. 1 T?4 is upregulated after axonal injury in both zebrafish and mice. a Expression profile of tmsb4x in the adult zebrafish spinal cord after injury. wpi, weeks post injury. Each group contains 5 samples, except for the 6 wpi caudal group, which contains 4 samples. b Expression profile of the Tmsb4x gene in DRG neurons at 72 h after sciatic nerve crush in mice, as determined by snRNA-seq analysis. "Naive" represents the group without crush injury, whereas "crush" represents the group that underwent crush injury. Cell numbers: Control, 6141; Crush, 5172. c Expression profile of Tmsb4x in RGCs with successful and failed axon regeneration following PTEN knockout, SOCS3 knockout, and CNTF overexpression. In this study, the authors used dextran micro-Ruby (MR) to retrogradely label RGCs with successful axon regeneration. "PSCCreMRneg" represents RGCs with failed axon regeneration and negative labeling of MR, while "PSCCreMRpos" represents RGCs with successful axon regeneration and positive labeling. Cell numbers: PSCCreMRneg, 66; PSCCreMRpos, 179