ZFIN Image: Naderi et al., 2024, Figure 3

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Figure Caption

Figure 3

Defects of excitatory/inhibitory balance in the kcc2a KO larvae. 10 μm coronal sections of 21 dpf (A) control (N = 4, n = 12), (B)kcc2a crispants (N = 3, n = 9) stained with gephyrin, an inhibitory post-synaptic scaffolding protein and (C) quantification of gephyrin puncta density. (D) Coronal sections of 21 dpf control (N = 3, n = 9) larvae and (E)kcc2a crispants stained with PSD-95, an excitatory post-synaptic scaffolding protein and (F) quantification of PSD-95 puncta density. (G) PSD-95/gephyrin puncta density ratio. Scale bar 10 μm. N, number of larvae; n, number of sections. The asterisks above data bars represent a significant difference vs. the control group at *p < 0.05, **p < 0.01, and ***p < 0.001. “ns” indicates not significant (p > 0.05).

Acknowledgments

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