ZFIN Image: Feng et al., 2024, Figure 4

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Figure Caption

Figure 4

siRNAs targeting zebrafish-specific lncRNAs exhibit specific cytotoxicity against human cancer cells without affecting mouse cancer cells (A, B) Representative microscopic pictures of HCT116, DLD1, and CT26 cells treated as indicated. Apoptotic and pyroptotic cells were denoted by red or yellow arrowheads, respectively. (C, D) Percentages of the area covered by living cells under specified treatments. Data were presented in the format of mean ± SD. Scale bar, 100μm. (E -H) Percentages of total cell death determined by flow cytometric analysis. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns, no significant difference.

Acknowledgments

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