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Fig. 9 Hypothetic mechanisms of SHK on the suppression of cell growth in vitro in CBF-AML cells and in vivo in zebrafish xenografts. SHK has been found to suppress the growth of CBF-AML Kasumi-1 cells by reducing cell viability, inducing cell cycle arrest, promoting cell apoptosis and differentiation, and downregulating AML1-ETO and c-KIT expression. In zebrafish xenografts, the SHK has been shown to markedly suppress the cell growth of CBF-AML Kasumi-1 cells in zebrafish xenograft models. Additionally, the combination of SHK with cytarabine has demonstrated a synergistic effect on decreasing cell viability in CBF-AML cells. (Created with BioRender.com).