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Fig. 7 AML-associated genes differentially expressed in SHK-treated Kasumi-1 cells. (A) The Venn diagram illustrates the intersection of the DEGs of SHK-treated cells with the set of AML-associated genes (DisGeNET CUI: C0023467). (B) The 14 upregulated and (C) the 35 down-regulated genes in response to SHK treatment found in the intersection are listed. (D) Predicted PPI network for the AML-associated genes downregulated by SHK was analyzed using the STRING database. (E) Kasumi-1 cells were treated with vehicle or SHK (0.4 ?M) for 48 h. The mRNA levels of PLK1 and AURKB were determined by RT-qPCR analysis. Data represent the mean ± SD of three independent experiments. **p < 0.01 indicates significant differences compared to the vehicle-treated cells.