Figure 4

Figure 4

Transcriptomic analysis in a zebrafish inflammation model treated with TnP. (A) Experimental design comprising Ahr2-knockdown (KD), TnP prophylactic treatment, and injury-induced inflammation model by tail fin amputation. (B) Principal component analysis (PCA) for the overall distribution of the datasets; the ellipses limit the 95% confidence interval among biological replicates. (C) Hierarchical clustering heatmap depicting gene transcription patterns; adjust p-value < 0.05 and log₂ fold change ±0.5. (D) Bar plots illustrating the differentially expressed genes (DEGs) between pairwise comparisons in both genotypes. (E) Venn diagrams of the overlapping and distinct DEGs in KD and wild-type (WT) groups modulated by TnP under inflammatory conditions.