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Fig. 8
Schematic presentation depicting the ADAMTS1–VCAN–EGFR axis in promoting the anoikis resistance and invasive abilities of renal cell carcinoma (RCC). ADAMTS1 mediates the proteolytic cleavage of VCAN V1, thereby activating EGFR cascades to promote anoikis resistance and invasion of RCC cells. Moreover, ADAMTS1 interacts with p53 to modulate EGFR expression. EGFR-driven signaling might potentially reinforce ADAMTS1 expression through positive feedback. Bold dashed oval and arrow indicate hypothetical molecules and pathways that participate in ADAMTS1-mediated EGFR activation or expression. The cyclic elevation of ADAMTS1 and EGFR exacerbates anoikis resistance and invasiveness in RCC cells