Fig. 1

Fig. 1

A. Heat map comparison of gene expression between control siblings (control) and partially paralyzed sofa potato mutants (sop^−/−). Omc5 gene is marked with an arrowhead. B. ddPCR of omc5 transcript in control embryos (control) and paralyzed mutants (sop^−/−) at 5 dpf. C. Diagram displaying protein products of omcin 1-15 along with human uromodulin, human GP2, and human uromodulin-like. Domains/motifs are indicated with colored squares. D. A map of ∼400 KB region on Chromosome 12 where a cluster of omcin genes are located. E. Phylogenetic tree for the amino acid sequences of the zebrafish omcin genes, zebrafish uromodulin-like gene, human uromodulin gene, human GP2 gene, and human uromodulin-like gene. Numbers in the nodes of the tree indicate bootstrap values.