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Fig. 5 The regulation of the cardiac muscle contraction signaling pathway is associated with indomethacin-induced cardiac disruption in zebrafish embryos. (A) Schematic diagram of cardiac muscle contraction and the key associated regulators. (B) Heatmap analysis of cardiac muscle contraction and the calcium signaling pathway in zebrafish embryos treated with different concentrations of indomethacin after 72 and 96 h of exposure. The pink grid represents upregulated genes, and the green grid represents downregulated genes. All the experiments were performed independently with three biological replicates.