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Fig. 2 Indomethacin exposure impairs cardiac development in zebrafish embryos. (A) Representative optical images of pericardial oedema in zebrafish embryos after exposure to indomethacin at 48, 72 and 96 h. Arrowheads, the pericardial areas. Scale bars, 200 µm. (B) Representative image (upper panel) and quantification (lower panel) of the distances between the venous sinus and bulbus arteriosus (SV-BA) of zebrafish embryos exposed to various concentrations of indomethacin for 48?96 h (n = 9 for each group). (C) Representative image (upper panel) and quantification (lower panel) of pericardial areas in zebrafish embryos treated with different concentrations of indomethacin for 48?96 h (n = 15 for each group). All the values are presented as the means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.