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Fig. 3 ccdc141 exhibited global effects on early signaling pathways in LR development. A?C: Expression patterns of spaw (A, 16 hpf), lefty2 (B, 17 hpf), and pitx2 (C, 18 hpf) in zebrafish embryos. Left (normal), right (abnormal), bilateral (abnormal), or absent (abnormal). D?F: The quantification of the gene expression. Cas9 vs. crispants, N = 3; n = 91/67 (D); n = 91/67 (E); n = 91/67 (F). ??, P < 0.01; ????, P < 0.0001; two sided Fisher's exact test. L, left; R, right.
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Reprinted from Journal of genetics and genomics = Yi chuan xue bao, 51(9), Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R., ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish, 934-946, Copyright (2024) with permission from Elsevier. Full text @ J. Genet. Genomics