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Monaghan et al., 2024 - FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms
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Fig. 1 Schematic representation of FLT4/VEGFR3 protein. Red bracket: location of missense or in frame indels identified in TOF. Black bracket: location of inframe MD variants. Blue bracket: location of TOF-PTVs (P30fs*3 to Y1337fs*19). The eight variants experimentally studied here are indicated. SRP, signal recognition peptide; IgDs, immunoglobulin-like domains.

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