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Fig. 2 OSBPL7 deficiency leads to ER stress and decreased autophagic flux. A and B: representative Western blot images (A) of PERK, IRE1α, PDI, phosphorylated and total SAPK/JNK, BiP, and GAPDH with quantification from three independent experiments (B). C and D: representative Western blot images (C) of LC3I, LC3II, and GATE16 levels with GAPDH loading control with quantification from three independent experiments (D). n = 3. *P < 0.05, **P < 0.01, and ***P < 0.005. BiP, binding immunoglobulin protein; ER, endoplasmic reticulum; IRE1α, inositol-requiring enzyme 1α; OSBPL7, oxysterol-binding protein-like 7; PERK, protein kinase RNA-like ER kinase; SAPK/JNK, stress-activated protein kinase/c-Jun N-terminal kinase.