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Fig. 12 The kcnk13 gene was duplicated in teleosts, including zebrafish. The molecular phylogenetic tree was generated using maximum likelihood analysis on vertebrate tandem pore domain halothane-inhibited K+ (THIK) channel proteins with Jones–Taylor–Thornton model plus gamma distribution. Numbers at each node denote bootstrap values based on 1000 replicates. Branch lengths are proportional to expected replacements per site. All the THIK members, KCNK12, KCNK13, KNCK19, and KCNK20, formed distinct clades. Teleost channel formed two subgroups, Kcnk13a and Kcnk13b, within the KCNK13 tandem of pore domains in a weak inward rectifying K+-related K channel clade. The zebrafish channels were highlighted in blue.