|
Fig. 8 Neutrophil immune profile controls spinal cord regeneration. Spinal cord injury induces a quick infiltration of neutrophils to the injury site. Conserved chemokine pathways control neutrophil infiltration dynamics. Inhibition of Cxcr4 induces early resolution of neutrophil inflammation, enhancing their activation state and production of the neural growth factor ndnf at the transcriptional level. These changes translate into transient increased expression of tnf-α in macrophage/microglia and promotion of axonal regrowth. Conversely, Cxcr1/2 inhibition besides delaying and attenuating neutrophil recruitment, induces a detrimental inflammatory profile in neutrophils, decreasing the accumulation of macrophage/microglia at the injury site and impairing axonal regrowth.