IMAGE

Fig. 8

ID
ZDB-IMAGE-240725-8
Publication
de Sena-Tomás et al., 2024 - Neutrophil immune profile guides spinal cord regeneration in zebrafish
All Figures
Figures for de Sena-Tomás et al., 2024
Image
Figure Caption

Fig. 8 Neutrophil immune profile controls spinal cord regeneration. Spinal cord injury induces a quick infiltration of neutrophils to the injury site. Conserved chemokine pathways control neutrophil infiltration dynamics. Inhibition of Cxcr4 induces early resolution of neutrophil inflammation, enhancing their activation state and production of the neural growth factor ndnf at the transcriptional level. These changes translate into transient increased expression of tnf-α in macrophage/microglia and promotion of axonal regrowth. Conversely, Cxcr1/2 inhibition besides delaying and attenuating neutrophil recruitment, induces a detrimental inflammatory profile in neutrophils, decreasing the accumulation of macrophage/microglia at the injury site and impairing axonal regrowth.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Brain Behav. Immun.
Your Input Welcome
We welcome your input and comments. Please use this form to report issues or recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.