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Fig. 2 Establishment of ULI-ssDRIP-seq, the R-loop profiling method for Ultra-low-input samples. A. Schematic of workflow of ULI-ssDRIP-seq method. B. IGV snapshots of zebrafish wR-loop (blue) and cR-loop (red) signals from ssDRIP-seq and ULI-ssDRIP-seq with different quantities of input. C. Metaplots and heatmaps of zebrafish wR-loop (blue) and cR-loop (red) signals from ssDRIP-seq (500k cells) and ULI-ssDRIP-seq with different quantities of input (10k, 1k, 100, or 10 cells). The signals around wR-loop (left) and cR-loop (right) peaks of 500k cells ssDRIP-seq were shown.
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