ZFIN Image: Choleva et al., 2024, Fig. 3

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Figure Caption

Fig. 3 PTN97–110 inhibits chick embryo CAM angiogenesis. Different amounts of the peptide were applied to the CAM and 48 h later, the total vessel length was estimated using image analysis software. Results are expressed as the percent change of the total vessel length in PTN97-110-treated compared with the vehicle (PBS)-treated CAMs (control) from at least four independent experiments. The box plots indicate the median, mean, and range of each group. Asterisks denote a statistically significant difference from the control. ***P < 0.001, ****P < 0.0001. The pictures are representative of the vessel network of the chicken embryo CAM.

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Reprinted from European Journal of Pharmacology, 977, Choleva, E., Menounou, L., Ntenekou, D., Kastana, P., Tzoupis, Η., Katraki-Pavlou, S., Drakopoulou, M., Spyropoulos, D., Andrikopoulou, A., Kanellopoulou, V., Enake, M.K., Beis, D., Papadimitriou, E., Targeting the interaction of pleiotrophin and VEGFA₁₆₅ with protein tyrosine phosphatase receptor zeta 1 inhibits endothelial cell activation and angiogenesis, 176692, Copyright (2024) with permission from Elsevier. Full text @ Eur. J. Pharmacol.