ZFIN Image: Song et al., 2024, Figure 7

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Figure Caption

Figure 7

C-terminal structural alignment of TRAF family members. (A) AlphaFold-predicted structure of TRAF7 CC and WD40 domains. The CC region (288–374 aa) is a long α-helix colored magenta, while WD40 (385–670 aa) is colored yellow. (B) Alignment of crystal structures of TRAF1–6 CC and TRAF-C regions. TRAF1–4 and TRAF6 are from humans, and TRAF5 is from mice. TRAF1–5 are homotrimers in crystals, which only show monomers. PDB ID: TRAF1, 5E1T; TRAF2, 1CA9; TRAF3, 1FLK; TRAF4, 3ZJB; TRAF5, 4GJH; TRAF6, 1LB4. (C) TRAF7 CC and WD40 trimer generated by AlphaFold2.3.1 with TRAF7 homotrimer input. (D) TRAF2 CC and TRAF-C trimer from the crystal structure (PDB ID: 1CA9). The CC domain (311–347 aa) is an α-helix colored cyan. The TRAF-C domain (352–501 aa) is colored slate blue.

Acknowledgments

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