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Fig. 6 Exposure to a ternary mixture of 1 mg/L MC-LR, 20 mg/L Dox, and 20 µM CMP5 significantly decreased the prmt5 expression and mean gray value (intensity/area) in krasV12 zebrafish larvae. (A)– (C): Representative pictures of zebrafish treated with 20 mg/L Dox, 1 mg/L MC-LR + 20 mg/L Dox, and 1 mg/L MC-LR + 20 mg/L Dox + 20 µM CMP5. Scale bar, 1 mm. (D)–(F): Representative histological images of krasV12 zebrafish liver. Scale bar, 50 µm. (G): Mean gray value (intensity/area) of krasV12 zebrafish larvae (n = 9). (H): Expression levels of the genes associated with tumor progression (n = 6). The significance of differences between control and exposure groups was evaluated using one-way ANOVA, followed by Tukey’s range test. Values are mean ± S.E. * p < 0.05, * * p < 0.01, * ** p < 0.001.