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Fig. 7 p38 MAPK, JNK, and Smad2/3 signaling pathways regulate the expression of nkx1.2. Nkx1.2 expression in 3T3-L1 cells treated with (A) p38 inhibitor, (B) ERK inhibitor, (C) JNK inhibitor, (D) Smad2/3 inhibitor, or (E) Smad1/5/8 inhibitor for 4 h and 24 h, respectively. (F) A model for the molecular mechanism by which Nkx1-2 regulates the adipogenesis. The beta-actin gene was used as loading control. Data were presented as mean ± SD. Data were analyzed by one-way ANOVA (*p < 0.05, **p < 0.01, ***p < 0.001). [Color figure can be viewed at wileyonlinelibrary.com]
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Full text @ Obesity (Silver Spring)