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Fig. 5 Function enrichment analysis visualised in a protein-protein interaction (PPI) network of significant differentially expressed proteins (DEPs) in copper (Cu) – stressed zebrafish. Larvae were exposed to 10.7 μg L−1 of Cu (EC50) for 48 h and DEPs were sorted by STRING and visualised using Cytoscape (average clustering coefficient 0.261). The network contains 66 nodes and 52 edges, and proteins with no interactions within the network (singletons) were omitted. Nodes are coloured by their log fold change with red filled nodes being upregulated and blue filled nodes being downregulated proteins, with intensity correlating to a greater fold change. Edges indicate protein-protein interactions determined by STRING and intensity is relational to its confidence score.