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Fig. 2 Mutations acquired during S. aureus sequential infections of macrophages. (A) Distribution of different types of mutations across the genomes and genes affected, colored by type of mutation. Mutations in isolates from passage cycles 4, 20, and 32 are plotted in the inner, middle, and outer circles, respectively. (B) Frequency of the types of mutations (from the 90 Illumina sequenced isolates per strain). (C) List of mutations found in more than three isolates in the passage cycle 4 (P4), 20 (P20), and 32 (P32), colored by the number of isolates with the mutation (from the five sequences per lineage, passage cycle, and strain). Synonymous mutations in italic.