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Fig. 1 Magnetic Resonance Images (MRI) of patient 1 and 3. T2-weighted images at the age of 5 days of patient 1 showed regions in both hemispheres with a simplified gyral pattern, indicated by blue arrows in (A), (B), and (C). The red arrow in (B) marks a possible abnormal lateral right temporal lobe, but the actual anatomy is obscured by a Gibbs artifact. MRI of patient 3 at the age of 4 years ([D] (FLAIR), [E] (T2 weighted), and [F] (T1 weighted) showed enlarged lateral and third ventricles, decreased volume of cerebral white matter and incomplete myelination, and pontocerebellar atrophy.
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