ZFIN Image: Aranda-Mart�nez et al., 2024, Figure 3

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Figure 3

Disruption of muscle growth and differentiation pathways during aging. (A) akt expression showed an age-dependent decrease. (B) p70s6k was significantly reduced as early as 10 months of age. (C) Myogenin expression demonstrated a progressive reduction, with statistical significance observed at 60 months. (D) prdm1a increased at 30 and 60 months but not statistically significantly. Data are presented as mean ± SEM (n = 6–8 animals/group). * p < 0.05 vs. 2 mo; ** p < 0.01 vs. 2 mo; *** p < 0.001 vs. 2 mo; # p < 0.05 vs. 10 mo. One-way ANOVA with a Tukey’s post hoc test.

Acknowledgments

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