ZFIN Image: Xia et al., 2024, Figure 3

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Figure Caption

Figure 3

The defects in PIKfyve mutants are dependent on sustained mTOR activation. (A) mTOR inhibitor (Rapa or Torin-1) treatment or effective mTOR knockout (mTOR_KO) attenuates the developmental defects in PIKfyve mutants. Scale bar, 20 µm. (B) Survival curve showing that the lifespan of MU embryos can be extended when mTOR is inhibited by chemical (Rapa, Torin-1) or genetic (mTOR_KO) approaches (N = 3, n = 30 per group). (** p < 0.01, log-rank test). (C) Quantification of diameter of macrophages in MU zebrafish embryos treated as in (A) (**** p < 0.0001, one-way ANOVA).

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