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Fig. 6 Anti-inflammatory drug rescue of Klebsiella pneumoniae-disrupted circadian rhythm genes. Zebrafish were infected with NTUH-K2044 for 48 hpf, followed by treatment with the anti-inflammatory drug G6PDi-1, and the expression of genes associated with circadian rhythm were evaluated in different groups of zebrafish at 5 dpf. qRT-PCR analysis of zebrafish clock genes per2 (A), cry1ab (B), cry1aa (C), and clock1a (D) in the control, NTUH-2044, and NTUH-2044+G6PDi-1 treatment groups. Each experiment was performed in triplicate. Data are expressed as the mean ± standard deviation (SD). Data were analyzed using Student's t-test. (**P < 0.01, ***P < 0.001).