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Figure 7.

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ZDB-IMAGE-240612-8

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Rahmati et al., 2024 - Fine-tuning amyloid precursor protein expression through nonsense mediated mRNA decay

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Figure 7.

Expression of app family genes in wild-type and appb^−/− embryos before and after knocking down NMD factors. A–C, Relative mRNA expression levels of appb, appa, aplp1, and aplp2 in uninjected wild-type embryos (N = 12–15), uninjected appb^−/− (N = 13–15), wild type injected with upf1MO (N = 12), upf2MO (N = 14), upf3a/upf3bMO (N = 13), and appb^−/− injected with upf1MO (N = 11), upf2MO (N = 12), and upf3a/upf3bMO (N = 15). n = 3 biologically independent samples. Data shown as mean + SD. Student's two-tailed t test were used to calculate p values. *p < 0.05, **p < 0.01, ***p < 0.005, and ****p < 0.0001. ns, nonsignificant.

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