mTOR signaling was activated in larval zebrafish tail fin after amputation. (A) Fin amputation model: the tail fin was amputated at 3 dpf. (B) The expression level of p-S6 in mTOR-WT larval zebrafish fin at different stages after amputation. (C) The expression level of S6 in mTOR-WT larval zebrafish fin at different stages after amputation. (D) Effect of mTOR inhibitors (Rapamycin and Torin1) on larval zebrafish fin regeneration after amputation. (E-F) Statistical analysis of fin regeneration area and rate in mTOR-WT zebrafish larvae after administration of Rapamycin and Torin 1. ***P < 0.001, ****P < 0.0001
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Full text @ J Orthop Surg Res
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