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Figure Caption
Fig 8 A model on the two synergistic mechanisms of zebrafish mylipb in negative regulation of antiviral innate immunity.
Upon viral infection, zebrafish rig-i/mda5 recognizes the viral RNA and interacts with mavs, leading to the recruitment of tbk1, which phosphorylates irf3 and then induces IFN production. Zebrafish mylipb, an E3 ubiquitin ligase, increases K6-linked polyubiquitination at Lys 352, leading to the induction of autophagic degradation of irf3, while at the same time reducing irf3 phosphorylation by acting as a substrate for tbk1, thereby preventing the expression of IFN.
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Full text @ PLoS Pathog.