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Fig. 10 Release of L3 from complex 5 (200 μM) when incubated with 3 equiv of H2O2 (600 μM) in 10 mM phosphate buffer (pH 7.4) with 4 mM NaCl. (A) HPLC traces at different time intervals showing the release of the free ligand in the presence of ROS and generation of the monoaquated complex and two other uncharacterized ligand bound complexes. Detector UV channel = 254 nm. (B) Plot of the percentage dissociation of 5 in the presence of 3 equiv of H2O2 and percentage release of L3. After 24 h, 25% ligand release was observed.
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Full text @ J. Med. Chem.