ZFIN Image: Hayasaka et al., 2024, Fig. 7

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Figure Caption

Fig. 7 Effects of Sirt1- and Igf1r-blockade on Mapk activation. Whole-mount immunostaining using anti-phospho-Erk1/2 antibody of drug-treated Reoxy embryos. Embryos at the beginning of Reoxy (36 hpf) were treated with either 50 µM EX-527, 2 µM BMS754807, or their combination for 12 hr, and subjected to the immunostaining experiment. Confocal images of each group of embryos are shown. Arrows indicate stronger phospho-Erk1/2-signals in control specimens. Fb, forebrain; Hb, hindbrain; MHB, midbrain-hindbrain boundary; Pa, pharyngeal arches; Sc, spinal cord; Sm, somite muscle. Directions of the specimen are shown by A(anterior)-P(posterior), D(dorsal)-V(ventral) indicator. Bar, 200 µm.

Acknowledgments

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