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Fig. 6 Effects of Sirt1- and Igf1r-blockade on embryonic growth. Embryos at the beginning of Reoxy (36 hpf) were treated with either 50 µM EX-527, 2 µM BMS754807, or their combination for 12 hr. The head-trunk angle was measured before and after the drug treatments to calculate the relative growth rate. The value of control group (DMSO) was set as 100%. Values shown are mean ± SD. Data were obtained from three independent assays. n = 39 (DMSO); n = 39 (EX-527); n = 39 (BMS754807); n = 42 (EX-527; BMS754807). Different letters mean statistical significance at P < 0.0001.
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