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Fig. 8 Gene regulatory network involving pou5f3 as a hub. NMPs maintained in the tail bud (stem zone) enter the transition zone, where they undergo neural specification (transit cells) and then progress into the maturation zone, where progenitors further enter the phase of neural differentiation.20 Arrows and T-shaped lines represent up-regulation and down-regulation, respectively. Black lines show regulation shown in the current study, whereas gray lines show established interactions or those reported recently.6 Thick lines show interactions confirmed by both LoF and GoF experiments, whereas thin lines show interaction inferred from LoF experiments (Table 1). The ??? marks show inconsistent results among experiments (Table 1). GoF, gain-of-function; LoF, loss-of-function; NMP, neuromesodermal progenitor.